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Table 3 Ontologies related to BTO that model MS aspects, part II

From: An extensible and unifying approach to retrospective clinical data modeling: the BrainTeaser Ontology

[19]

Name

Multiple Sclerosis Ontology (MSO)

Usage

TH, AI

Online

Partially (Released: 2014). The ontology is available at https://bioportal.bioontology.org/ontologies/MSO but the MSO for classes defined within MSPD are broken or non-existent.

Description

Automatically constructed ontology for terms associated with MS to enhance information retrieval models.

Differences

Thesaurus containing concepts related to the MS and their relation, without focusing on the patient’s clinical history.

[20]

Name

Universal Immune System Simulator (UISS)

Usage

TH, AI

Online

No

Description

Ontology used to describe the specific autoimmune biochemical interactions during MS dynamics to computationally predict its course.

Differences

UISS focuses mainly on biochemical aspects of the MS and does not consider aspects related to the clinical history of the patients, the most relevant aspect in BTO.

[21]

Name

Symptomatic Treatment of Multiple Sclerosis Ontology (STMSO)

Usage

TH, KB

Online

Yes (Released: 2022) https://bioportal.bioontology.org/ontologies/STMSO

Description

The STMSO is a rich ontology to model the symptomatic treatment of the patients.

Diffences

STMSO focuses on the symptomatic treatment and is meant to model static data. It does not allow for modelling the clinical history of the patients as a sequence of temporal events (i.e., the medical prescriptions over time). Furthermore, the ontology does not define ranges, domains, constrains, and data types for data and object properties.