Fig. 11

An example for a pairwise relationship limitation type “More than two entities interacting together”. Left (a): Each of three biomarkers (plasma A\(\beta\)42/40 ratio, ApoE proteotype, and age) is connected to a general concept a blood-based diagnostic test with a relation of incorporate. a blood-based diagnostic test is a subject that identifies brain amyloid status. Right (b): One limitation of “More than two entities interacting together” is removed with a hypergraph. Three biomarkers are reified as an entity (denoted as reified A). A reified biomarker is linked with a general concept a blood-based diagnostic test with a relation of is_a