Fig. 9

An example for a pairwise relationship limitation type “Modifier that adds granular information for entities”. Left (a): A modifier widespread and a corresponding genotype cortical amyloid-\(\beta\) pathology are connected with a relation of modify. An entity plasma p-tau181 increase is associated with an entity cortical amyloid-\(\beta\) pathology only. Right (b): widespread pointing to cortical amyloid-\(\beta\) pathology with a relation of modify is grouped as a nested entity. plasma p-tau181 increase is associated with a granular entity. To avoid confusion for another limitation type, we fix the limitation type of “‘Mechanism/process from a modified entity” for the entity “plasma p-tau 181 increase”, which is a nested entity by grouping “plasma p-tau 181” and “increase”